Radicofani is a comune in the Province of Siena in the Italian region Tuscany, located in the natural park of Val d'Orcia about 110 kilometres southeast of Florence and about 60 kilometres southeast of Siena. Radicofani borders the following municipalities: Abbadia San Salvatore, Castiglione d'Orcia, Pienza, San Casciano dei Bagni, Sarteano.