Columbia County is a county located in the north central portion of the U.S. state of Florida. As of the 2020 census, the population was 69,698, up from 67,531 at the 2010 census. Its county seat is Lake City. Columbia County comprises the Lake City, FL Micropolitan Statistical Area, which is included in the Gainesville-Lake City, FL Combined Statistical Area. Osceola National Forest is partially in Columbia County.