Clarke County is a county located in the southwestern part of the U.S. state of Alabama. As of the 2020 census, the population was 23,087. The county seat is Grove Hill. The county's largest city is Jackson. The county was created by the legislature of the Mississippi Territory in 1812. It is named in honor of General John Clarke of Georgia, who was later elected governor of that state. The county museum is housed in the Alston-Cobb House in Grove Hill.