Creve Coeur is a city located in mid St. Louis County, Missouri, United States, a part of Greater St. Louis. Its population was 18,834 at the 2020 census. Creve Coeur borders and shares a ZIP code with the neighboring city of Town and Country. It is home to the headquarters of Drury Hotels, and was the home of Monsanto until its acquisition by Bayer in 2018.