Midpines is a census-designated place in Mariposa County, California. It lies among the Sierra Nevada foothills of the central part of the state at an elevation of 2,585 feet, 5 miles northeast of Mariposa, the county seat, and 22 miles by road southwest of El Portal. It is composed of scattered residential areas along both sides of State Route 140, which is one of three principal routes to Yosemite National Park, some 30 miles to the east of Midpines.