Eunice is a city in Acadia and St. Landry parishes in the U.S. state of Louisiana. The 2010 census placed the population at 10,398, a decrease of 1,101, or 9.5 percent, from the 2000 tabulation of 11,499. The St. Landry Parish portion of Eunice is part of the Opelousas–Eunice Micropolitan Statistical Area, while the Acadia Parish portion is part of the Crowley Micropolitan Statistical Area.