Escambia County is a county located in the south central portion of the U.S. state of Alabama. As of the 2020 census, the population was 36,757. Its county seat is Brewton. Escambia County is coextensive with the Atmore, AL Micropolitan Statistical Area; which is itself a constituent part of the larger Pensacola-Ferry Pass, FL-AL Combined Statistical Area. The county is the base of the state's only federally recognized Native American tribe, the Poarch Band of Creek Indians.