Scottsbluff is a city in Scotts Bluff County, Nebraska, United States, in the Great Plains region. The population was 14,436 at the 2020 census. Scottsbluff is the largest city in the Nebraska Panhandle, and the 13th-most-populous city in Nebraska. Scottsbluff was founded in 1899 across the North Platte River from its namesake, a bluff that is now protected by the National Park Service as Scotts Bluff National Monument.