Lone Pine is a census-designated place in Inyo County, California, United States, located 16 mi south-southeast of Independence. The population was 2,035 at the 2010 census, up from 1,655 at the 2000 census. The town is located in the Owens Valley, near the Alabama Hills and Mount Whitney, between the eastern peaks of the Sierra Nevada to the west and the Inyo Mountains to the east. The local hospital, Southern Inyo Hospital, offers standby emergency services.