Weirton (pron. WEER-ton) is a city in Brooke and Hancock counties in the U.S. state of West Virginia. Located primarily in Hancock County, the city lies in the northern portions of the state's Northern Panhandle region. As of the 2010 census, the city's population was 19,746. It is a principal city within the Weirton-Steubenville, WV-OH Metropolitan Statistical Area, which had a population of 124,454 residents.