Wexford County is a county in the Northern Lower Peninsula of the U.S. state of Michigan. As of the 2020 United States census, the population was 33,673. The seat of Wexford County is Cadillac, which is also the county's largest city. Wexford County is largely covered by the Manistee National Forest, and thus is heavily wooded. The Manistee River flows from east to west in the north of the county.