Middleborough is a town in Plymouth County, Massachusetts, United States. The population was 24,245 at the 2020 census. The census-designated place of Middleborough Center corresponds to the main village and commercial center of the town. It is the second largest municipality by land area in Massachusetts and nineteenth largest in New England. Middleborough proclaims itself to be the "Cranberry Capital of the World". Cranberry production remains a significant part of the local economy.