Wyandotte is a city in Wayne County in the U.S. state of Michigan. The population was 25,058 at the 2020 census. Wyandotte is located in southeastern Michigan, approximately 11 miles south of Detroit on the Detroit River, and it is part of the collection of communities known as Downriver. Wyandotte is bounded by Southgate to the west, Lincoln Park to the northwest, Riverview to the south, Grosse Ile Township to the southeast, Ecorse to the north, and LaSalle, Ontario on the east.