Strong City is a city in Chase County, Kansas, United States. Originally known as Cottonwood Station, in 1881 it was renamed Strong City after William Barstow Strong, then vice-president and general manager, and later president of the Atchison, Topeka and Santa Fe Railway. As of the 2020 census, the population of the city was 386. It is located along U.S. Route 50 highway.