Homerville is an unincorporated community in central Homer Township, Medina County, Ohio, United States. It has a post office with the ZIP code 44235. It lies at the intersection of U.S. Route 224 with State Route 301. Homerville is situated in the rural quad-county area where Ashland, Lorain, Medina, and Wayne Counties meet. The economy is based largely upon agriculture, including livestock raising, dairy farming, and crop farming.