Keytesville is a city in and the county seat of Chariton County, Missouri, United States. The population was 440 as of the 2020 census. Keytesville is the hometown of U.S. Army General Maxwell D. Taylor, who commanded the "Screaming Eagles" 101st Airborne division during the Normandy invasion of World War II. Confederate General Sterling Price, who attacked Keytesville during an unsuccessful cavalry raid across his home state, had previously operated a hotel there.