Ennice is an unincorporated community in Alleghany County, North Carolina, United States. Ennice is located on North Carolina Highway 18, 7.7 miles east-northeast of Sparta. Ennice has a post office with ZIP code 28623, which opened on March 6, 1888. At the time of European colonization, the region surrounding Ennice and Alleghany County was home to Native American tribes, including the Cherokee and Shawnee.