Escambia County is the westernmost and oldest county in the U.S. state of Florida. It is in the state's northwestern corner. At the 2020 census, the population was 321,905. Its county seat and largest city is Pensacola. Escambia County is included within the Pensacola-Ferry Pass-Brent, Florida, Metropolitan Statistical Area. The county population has continued to increase as the suburbs of Pensacola have developed.