LaCrosse is a town in Alachua County, Florida, 15 miles north of Gainesville. The LaCrosse is part of the Gainesville, Florida Metropolitan Statistical Area. As of the 2020 US census, the town population was 316, down from 360 in 2010 US Census. The area around LaCrosse is devoted to agriculture, especially potatoes; the area is known as the "Potato District." Other products of the area include tobacco, vegetables, and cattle.