Jefferson is a town in western Chesterfield County, South Carolina, United States at the junction of SC routes 265 and 151. Jefferson is located in the Piedmont region of South Carolina just in the edge meeting the Sandhills region. Jefferson is located 16 miles northwest of McBee, 8 miles south of Pageland, 50 miles southeast of Charlotte, North Carolina, and 70 miles north-northeast of the state capitol Columbia. As of the 2010 census, the city population was 753.