Holopaw is an unincorporated community in Osceola County, Florida, United States. It is located at the eastern end of the multiplex of highways US 192 and US 441. It has a population of fewer than 5,000 people and is part of the Orlando-Kissimmee Metropolitan Statistical Area. Holopaw, a Creek Indian word meaning "Walkway" or "Pavement", was a stop along the Kissimmee Valley extension of the FEC railroad.