Sainte-Hénédine is a parish municipality in La Nouvelle-Beauce Regional County Municipality in the Chaudière-Appalaches region of Quebec, Canada. Its population is 1,440 as of the Canada 2021 Census. It is named after Catherine-Hénédine Dionne, widow of Pierre-Elzéar Taschereau, who owned the two seigneuries from which the territory of Sainte-Hénédine was detached.