Forsyth County is located in the northwest Piedmont of the U.S. state of North Carolina. As of the 2020 census, the population was 382,590, making it the fourth-most populous county in North Carolina. Its county seat is Winston-Salem. Forsyth County is part of the Winston-Salem, NC, Metropolitan Statistical Area, which is also included in the Greensboro–Winston-Salem–High Point, NC, Combined Statistical Area. Portions of Forsyth County are in the Yadkin Valley wine region.