San Giovanni al Natisone is a comune in the Regional decentralization entity of Udine in the Italian region of Friuli-Venezia Giulia, located about 50 kilometres northwest of Trieste and about 15 kilometres southeast of Udine. San Giovanni al Natisone borders the following municipalities: Chiopris-Viscone, Cormons, Corno di Rosazzo, Manzano, Trivignano Udinese.