Otay Mesa West is a residential neighborhood in the southern section of San Diego, California. It borders Interstate 805 to the east, Interstate 5 to the west, and California State Route 905 to the south. It neighbors Ocean View Hills to the east, Nestor and Palm City to the west and Chula Vista to the north. The northern boundary of Otay Mesa West roughly coincides with the Otay River. Just north of the Otay River the community of Otay resides within the city of Chula Vista.