Santarcangelo di Romagna is a comune in the province of Rimini, in the Italian region of Emilia-Romagna, on the Via Emilia. As of 2009, it had a population of some 21,300. It is crossed by two rivers, the Uso and the Marecchia. The municipality includes much of the town of San Vito, notable for the Ponte di San Vito and the Sanctuary of Madonna di Casale.