Maysville is a home rule-class city in Mason County, Kentucky, United States, and is the seat of Mason County. The population was 8,873 as of the 2020 census. Maysville is on the Ohio River, 66 miles northeast of Lexington. It is the principal city of the Maysville Micropolitan Statistical Area, which comprises Mason County. Two bridges cross the Ohio from Maysville to Aberdeen, Ohio: the Simon Kenton Memorial Bridge built in 1931 and the William H. Harsha Bridge built in 2001.