Clayton–Tamm is a historic St Louis neighborhood and once an Irish-American enclave located near the western border of St. Louis, Missouri, USA, just south of Forest Park. Its borders are Hampton Avenue to the east, Manchester Road to the south, Louisville Avenue on the west, and Oakland Avenue and I-64 to the north. Its name is derived from the intersecting streets of Clayton Avenue and Tamm Avenue, which is the center of the neighborhood's business district.