Guadalupe is a town in Maricopa County, Arizona, United States and part of the greater Phoenix metropolitan area. The town motto, "where three cultures flourish", recognizes the town's roots in the Yaquis, Mexicans and descendants of the original farmers. Since its founding, Guadalupe has been known as a center of Yaqui culture, and it is home to many religious festivals. Nestled between Phoenix and Tempe, the 2020 census listed the population of the town as 5,322.