Ortezzano is a comune in the Province of Fermo in the Italian region Marche, located about 70 kilometres south of Ancona and about 20 kilometres north of Ascoli Piceno. As of 31 December 2004, it had a population of 834 and an area of 7.0 square kilometres. Ortezzano borders the following municipalities: Carassai, Montalto delle Marche, Monte Rinaldo, Monte Vidon Combatte, Montottone.