The Town of Gypsum is the home rule municipality that is the most populous municipality in Eagle County, Colorado, United States. The town population was 8,040 at the 2020 United States Census, a+24.13% increase since the 2010 United States Census. Gypsum is a part of the Edwards, CO Micropolitan Statistical Area. Gypsum is the home of an American Gypsum drywall plant and mine.