Chattahoochee is a city in Gadsden County, Florida, United States. Its history dates to the Spanish era. It is part of the Tallahassee, Florida Metropolitan Statistical Area. The population was 2,955 as of the 2020 census, down from 3,652 at the 2010 census. Chattahoochee sits on the banks of the Apalachicola River, and is separated by the Apalachicola and Victory bridges from neighboring Sneads, Florida, which is in Jackson County.