Roxborough is a neighborhood in Northwest Philadelphia, Pennsylvania, United States. It is bordered to the southwest, along the Schuylkill River, by the neighborhood of Manayunk, along the northeast by the Wissahickon Creek section of Fairmount Park, and to the southeast by the neighborhood of East Falls. Beyond Roxborough to the northwest is Montgomery County. Roxborough's ZIP Code is 19128. Most of Roxborough is in Philadelphia's 21st Ward.