Trego is an unincorporated census-designated place located in the town of Trego, Washburn County, Wisconsin, United States. Trego is located at the junction of U.S. Highway 53 and U.S. Highway 63, 6 miles north-northeast of Spooner. Trego has a post office with ZIP code 54888. As of the 2010 census, its population is 227.