Roxana is a village in Madison County, Illinois, United States. The population was 1,454 at the 2020 census. The ZIP Code is 62084. A majority of the land in Roxana is taken up by the Wood River Refinery, an oil refinery operated by Phillips 66. The refinery was originally built and owned by Shell Oil. As of 2016, the refinery is capable of refining 314,000 barrels of oil per day to produce gasoline, jet fuel, diesel, asphalt, propane, and other products, and supplies part of the St. Louis, Chicago, Indiana, and Ohio regions.