Orange County is a county located in the Piedmont region of the U.S. state of North Carolina. As of the 2020 census, the population was 148,696. Its county seat is Hillsborough. Orange County is included in the Durham-Chapel Hill, NC Metropolitan Statistical Area, which is also included in the Raleigh-Durham-Cary, NC Combined Statistical Area, which had an estimated population of 2,368,947 in 2023.