Topolobampo is a port on the Gulf of California in northwestern Sinaloa, Mexico. It is the fourth-largest town in the municipality of Ahome, reporting a 2010 census population of 6,361 inhabitants. The port connects the northern Mexican states through the Chihuahua-Pacific Railroad, which has a terminus in nearby Los Mochis. It is the eastern port for the daily car ferry connecting to La Paz in Baja California Sur.