Perkins is an unincorporated community and census-designated place in western Scott County, Missouri, United States. It is located sixteen miles northwest of Sikeston. A post office called Perkins has been in operation since 1890. The community has the name of Amos Perkins, a businessperson in the local lumber industry. Perkins is found in the St. Louis Southwestern Railway Northern Division Employee Time Table No. 10 dated August 18, 1935. Perkins was station I-24 at milepost 23.76.