Cascade is a city in Dubuque and Jones counties, Iowa, United States. The Dubuque County portion is part of Dubuque Metropolitan Statistical Area, while the Jones County section is part of Cedar Rapids Metropolitan Statistical Area. The population was 2,386 at the 2020 census, up from 1,958 in 2000. The city is located within southwestern of Dubuque County and north-central Jones County. Arguably the town's most notable historic event was the 1925 flood.