Jackson is a city in and the county seat of Madison County, Tennessee, United States. Located 70 miles east of Memphis, it is a regional center of trade for West Tennessee. Its total population was 68,205 as of the 2020 United States census. Jackson is the primary city of the Jackson, Tennessee metropolitan area, which is included in the Jackson-Humboldt, Tennessee combined statistical area. Jackson is Madison County's largest city, and the second-largest city in West Tennessee after Memphis.