Darmstadt is a city in the state of Hesse in Germany, located in the southern part of the Rhine-Main-Area. Darmstadt has around 160,000 inhabitants, making it the fourth largest city in the state of Hesse after Frankfurt am Main, Wiesbaden, and Kassel. Darmstadt holds the official title "City of Science" as it is a major centre of scientific institutions, universities, and high-technology companies.