Pittsford Mendon High School is a public high school in suburban Rochester, Monroe County, upstate New York. It is one of two high schools in the Pittsford Central School District, the other being Pittsford Sutherland High School. Pittsford Mendon is located at 472 Mendon Road (from which the school gets its name) in the town of Pittsford, near the town of Mendon, New York.