Plaza Las Delicias is the main plaza in the southern town of Ponce, and dates back to the early Spanish settlement in 1670. Its famous lion fountain is a major attraction, and the plaza is surrounded by many historic buildings, including Ponce Cathedral and Ponce City Hall.

One of Puerto Rico's most recognizable landmarks, Parque de Bombas is located in Ponce's enchanting town square. The building once housed a fire station and is now home to a small museum.

Discovered in 1847, Coamo Hot Springs is a relaxing oasis nestled in Puerto Rico's mountains. The springs offer two thermal pools along with a spa, gift shop and café.

Castillo Serrallés was built in the 1930s by the Serrallés family, founders of the famous Don Q Rum brand. It has a museum, butterfly nursery and Japanese garden. The museum houses a permanent exhibit and offers guided tours upon request.

Casa Museo de Los Santos Reyes is exclusively dedicated to the history of Three Kings Day (Epiphany), a tradition for most Latin American cultures. The museum is located in the town of Juana Díaz, which hosts the Island's annual Epiphany celebration.

The Museo Olímpico de Puerto Rico is dedicated to the collection, conservation, documentation and promotion of the history of Puerto Rican sports and athletes.

Caja de Muertos is a secluded and uninhabited nature reserve located off the southern coast of Puerto Rico. It's home to one of the region's most renowned beaches, Pelícano Beach, as well as lighthouse ruins and hiking trails. The island can be accessed by boat tour or private boat charter.