Above Board, which debuted on the World’s 50 Best Bars last year, is up some dingy stairs, behind a craft beer joint. The intimate venue is modern, minimalist and all about the drinks. The menu is non-negotiable, mixing subtly novel takes on classic cocktails such as the old fashioned and the Negroni, with more exotic concoctions all designed by convivial co-owner and cocktail maestro Hayden Lambert. For something new, try the margarita-styled Hot Minute.

The entrance may evoke its office block past, but head two flights down and you’ll land in an old-time world of booze and blues. In this candlelit basement bar, an eclectic drink list matches the bourbon-soaked sounds of B.B. King and Buddy Guy in the background. Try the Red Light Fizz (A$21; less than $14), where rum’s poured into a flaming passionfruit—a Melbourne take on the Pornstar Martini. Snackers have the option of small plates such as fresh oysters or raclette cheese toasts.

“Boilermaker” is a polite term for a whisky chaser, which this genteel haunt has elevated to an art form. The mind-boggling array of whiskies ranges from single malt scotch to Kentucky bourbon, and there’s a compelling craft beer list. A helpful menu of eight boilermakers pairs whiskies with ideal beer accompaniments, teasing out flavors from orchard fruits to freshly cut grass. The trans-Atlantic drink selection is matched with wood cabin decor.

Bouvardia has one of the city’s more interesting drink menus. This upstairs venue on a northern stretch of Bourke Street is lined with plush pink velvet seats and boasts a cocktail list that changes seasonally. Go for the David Bowie-inspired Major Tom, and not just for Instagram: The emerald green blend of passionfruit, mandarin curacao and amazake cream, made from the Japanese fermented drink, tastes exquisite, too.

Nestled among Port Melbourne’s casual eateries, Clooney Kitchen and Bar is an unexpected delight for a drink after a bayside evening stroll or a crawl of the suburb’s traditional pubs. On the signature drink menu, the pisco sour is a refreshing warm-weather tonic, while the Aye Aye Captain is a cheeky mix of rum with an infusion of popcorn. Clooney is a small and cozy affair, with a striking back-lit bar and a chill background soundtrack.

Don’t be fooled by the charming clock shop that greets visitors to the W Melbourne’s signature bar. It disguises the location of this Gen Z drinking cave. Chrome pillars meet latticed timber panels and velvet sofas in a dimly lit space oozing late-night romance. The Sonic Cymatics cocktail (A$25) is a whiskey-and-vermouth treat dressed with a QR code; when scanned, it plays a techno track that Curious says helps speed the whiskey’s aging process via musical vibrations.

Our barman called this classy cocktail and fine-dining parlor “the Titanic before it sank.” (We thought it was more like The Great Gatsby, but you get the picture.) There’s a perpetual buzz at the 1920s-built Cavendish House, a stone’s throw from the Grand Hyatt. Grab a dangerously comfortable stool at the black marble bar and watch the action unfold. The signature gimlet (A$22) is a tart but subtly sweet mix of gin, moscato and citrus cordial, garnished with a gorgeous native flower.

Open almost around the clock, the street-level HER Bar offers cocktails in a bistro setting, whether you want a bacon-egg roll washed down with an Aperol sour or an espresso martini. The upstairs Music Room offers whiskey alongside a wall of vinyl records, while the BKK canteen on the next floor serves Bangkok-inspired street food. The top-level HER Rooftop was made for summer with expansive views of the CBD, late-night tunes and a notable charred pineapple margarita.

With its unremarkable exterior, it’s easy to miss this Northcote gem. There’s an abundance of warmth and succor; the Danish cliché hygge comes to mind. Within the softly lit space, sofas are clustered into nooks, records spin on a turntable from the wooden bar and there's even a crackling fireplace. The cocktail list includes all the classics as well as show-stealing signatures, like the delightful 1’nce Again, which mixes dark rum, wattle seed, chocolate, espresso and a dash of salt.

Swing open the glass door, head up some dimly lit stairs and waltz in to the swankiest soirée in the business district. An ode to old Hollywood, Nick & Nora’s is an art deco lounge dripping with 1930s glamour that boasts a mix of classic and theatrical cocktails along with a river of Champagne. The Cafe Noir (A$22), an elegant espresso martini riff, is finished with a shot of liquid nitrogen that leaves an alluring mousselike top swirling in fog.

There’s plenty of fun to be found at this Collingwood rooftop bar, where the bartenders are as happy as the patrons. Once the not-so-easy-to-find elevator drops you at the pastel pink entrance, you’re treated to enviable views of the city’s skyline and its sunsets. If weather permits (there’s also an indoor bar), laze among the blossoming fruit trees while sampling the small but well-mixed cocktails that blend summery Italian classics with Australian flavors.

Think cigars, the romance of white tablecloths and multiple rounds of cocktails and Champagne. From an expansive terrace accessed by wraparound timber stairs, Siglo commands striking views of Melbourne’s neoclassical Parliament House and the nearby St Patrick’s Cathedral spire. After-work and weekend drinkers lounge in Parisian wicker chairs as they peruse a wonderfully dense European drink menu, as well as a large selection of Cuban Havanas.