If you’ve ever wanted to step inside a postcard, this is it. Fair Oaks has been a South Pasadena landmark since 1915, and the pharmacy plus soda fountain combo is the whole point. Order a classic shake, a float, or something delightfully old-timey, then wander the aisles like you are stocking up for a 1950s road trip. Bonus: it’s a beloved stop along the Route 66 story.

Founded in 1838, C.O. Bigelow is widely credited as America’s oldest apothecary, and it still operates in Greenwich Village. Expect a charmingly packed shop of pharmacy staples, plus a global snack bar of grooming and beauty finds, like Italian toothpastes and old-school remedies. It feels like a tiny museum where you can actually buy things, and yes, it’s still a real pharmacy.

Come for the prescriptions, stay for the lunch counter energy. ADD has served Athens since 1961, and it still nails that classic neighborhood drugstore vibe. Grab a no-fuss breakfast or lunch at the counter (the chili dogs are amazing), then browse the fun gift-y stuff like candles and kitschy souvenirs. It’s nostalgic in the best way.

Pickwick is a family-owned pharmacy that leans hard into the soda-fountain charm, complete with classic counter seating and a menu that makes adults act like kids. A great detail: the soda fountain itself was salvaged and restored, a 1949 beauty brought back to life so the shop could return to its roots. Don't leave without ordering a malt or some Pink Mama's ice cream.

This third-generation pharmacy has been serving Ely since 1946, and it openly brags about the soda fountain inside. As it should. Pick a sandwich, an ice cream situation (try smothered churros), or a fountain drink, then enjoy the small-town magic of getting comfort food while your prescription is filled. It’s one of those places that makes you want to start collecting postcards again.

Wall Drug started as a humble pharmacy in 1931 and somehow became one of America’s most famous roadside stops. It’s still rooted in the original drugstore story, but today it’s a sprawling, wildly entertaining complex of shops, photo ops, and classic South Dakota kitsch. The legend lives on with its free ice water tradition and iconic highway signs on display. Of course, you can't leave without grabbing a homemade donut.

Family-owned and operated since 1930, Hoskins is a real pharmacy paired with a full soda fountain and grill in historic downtown Clinton. Come hungry for malts and burgers, and get to know the locals who frequent the joint. If you collect retro souvenirs, this spot is a must-visit.

This is your official excuse to try a phosphate drink like it’s 1933, because that’s when this soda fountain tradition began. Grants Pass Pharmacy is still a functioning pharmacy, but the star is the historic fountain where you can order floats, phosphates, and hand-packed milkshakes.