Mykonos is already as desirable as any destination in the Mediterranean, and the luxe and alarmingly stylish Kalesma only raises the stakes. It’s set on a hilltop on the island’s west side, fifteen minutes from town, and feels like a private refuge — one whose 25 suites and villas pay tribute to classic Cycladic architecture as well as modern interior design, and feature Rick Owens furnishings among their adornments.

Any hotel that’s going to stand out in Santorini is going to do it by virtue of the fine details — and there will be guests for whom only La Perla, with its particular vision of modern-classic Cycladic hospitality, will do. The genre is subtle, modernist-inflected luxury, with boutique-hotel characteristics, and the color scheme sports a diverse array of greens, blues, and violet, against a backdrop of white and gray.

Soho House’s expansion is notable not only for how well its urban-creative members’-club concept has traveled, but for how effortlessly the brand has developed an equally strong line of far-flung destination clubs — including Soho Roc House, a 45-room escape on the south coast of Mykonos, close enough to the beaches and nightlife to feel convenient but removed enough to offer the privacy a members’ club demands.

Named for the volcanic rock on which it stands, Magma Resort Santorini makes a powerful argument for the outer edge of this crescent-shaped island. It faces the Aegean rather than the inner caldera, which trades one dramatic view for a rather subtler one — and which affords the resort a substantial expanse of extra space, allowing its rooms and suites to spread to luxurious dimensions.

The mythical hydra has many heads, but the island of the same name has only one sandy beach — and it’s on this idyllic stretch of sand that you’ll find the Mandraki Beach Resort, a modern luxury resort built on the site of a 19th-century naval fortification. It’s this curious history that explains the aesthetic; one part weathered stone and one part crisp, contemporary minimalism.

With NOŪS, Dakis Joannou, the industrialist and art collector, has created a hotel that doesn’t need a caldera view to supply a visual identity. Here a village-like collection of modern minimalist buildings — clearly descended from, but not in imitation of, the local village vernacular — stands around the centerpiece of a man-made water feature, a 50-meter L-shaped infinity pool.

Perhaps inspired by similarly situated dwellings on the island of Santorini, Acro Suites brings cliffside romance and carved-rock drama to the north coast of Crete. This adults-only resort-style luxury boutique hotel is the smaller and more reserved sister to the Sea Side Resort, right next door — an arrangement that allows Acro Suites’ guests to use Sea Side’s substantial facilities, but not the other way around.

A relatively remote corner of the eastern end of Crete is where you’ll find White River Cottages, a collection of stone houses in a valley called Aspros Potamos, whose direct translation gives the hotel its name. It’s a refreshingly tranquil and pastoral experience, with access to some impressively wild countryside and with an atmosphere that’s a fine mix of rough-edged rustic charm and contemporary boutique-hotel polish.

Cosme is set in the village of Naoussa, on the northern coast of Paros, an island that’s rather more tranquil than some of its neighbors, though hardly less desirable. In its 40 suites you’ll find a thoughtful, tasteful approach to luxury, and a style that’s memorable and modern while remaining unobtrusive — as always, the setting and the seascapes are the main attraction.